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. 2017 Feb 15;8(17):28575–28587. doi: 10.18632/oncotarget.15338

Figure 3. High SLFN11 and Low ATM Levels Maintain Sensitivity to PARP Inhibition and Chemotherapy.

Figure 3

A, and B. Silencing of SLFN11 with siRNA in DMS79 and H209 SCLC cell lines (which have high SLFN11 expression levels, are sensitive to PARP inhibition, and have no ATM mutations), increases the cells’ resistance to cisplatin, talazoparib and olaparib. C, and D. ATM knockdown increases sensitivity to cisplatin, talazoparib, and olaparib. siRNA effectively reduced SLFN11 and ATM. E. ATM inhibition sensitizes cell lines with low SLFN11 expression to PARP inhibition. The ATM inhibitor KU55933 plus talazoparib or olaparib was more effective in SCLC cell lines with lower SLFN11 levels.