Table 1. Markers of talazoparib (PARP inhibitor) response in PDX models of SCLC.

Markers of Talazoparib Response in vivo (PDX)
	Marker	P-value	Fold Change
Sensitivity	SLFN11 (protein)	0.013	5.10
	SLFN11 (mRNA)	0.031	38.82
	E-cadherin (protein)	0.158	2.24
	CDH1 (mRNA)	0.137	7.11
Resistance	EMT score	0.05	−2.24(mean difference)
	ATM (protein)	0.009	−2.32
	ATM (mRNA)	0.004	−2.12
	CHK1 (protein)	0.017	−1.48
	CHEK1 (mRNA)	0.003	−1.86
	IGF-1R (protein)	0.044	−1.73
	IRS1 (protein)	0.025	−1.39
Not Associated	Myriad HRD	0.748	1.081
	FMI Non-germline mutations	0.083	−1.514
	FMI All mutations	0.156	−1.347
	PAR (ELISA)	0.124	1.67
	PARP1 (protein)	0.614	−1.06