Table 5. Diagnostic thresholds of noninvasive models for liver fibrosis and cirrhosis.
| Cut-offs | Youden Index | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | PLR | NLR | |
|---|---|---|---|---|---|---|---|---|
| GPR | ||||||||
| ≥ F2 | 0.49 | 0.63 | 83 | 80 | 65 | 91 | 4.15 | 0.21 |
| ≥ F3 | 0.62 | 0.65 | 90 | 75 | 39 | 98 | 3.57 | 0.13 |
| = F4 | 0.74 | 0.81 | 100 | 81 | 30 | 100 | 5.26 | 0 |
| APRI | ||||||||
| ≥F2 | 0.41 | 0.39 | 80 | 59 | 47 | 87 | 1.96 | 0.33 |
| ≥ F3 | 0.44 | 0.36 | 80 | 56 | 25 | 94 | 1.81 | 0.36 |
| = F4 | 0.55 | 0.69 | 100 | 69 | 21 | 100 | 3.18 | 0 |
| FIB-4 | ||||||||
| ≥ F2 | 0.77 | 0.22 | 86 | 36 | 37 | 84 | 1.32 | 0.41 |
| ≥ F3 | 0.83 | 0.38 | 95 | 43 | 23 | 98 | 1.67 | 0.12 |
| = F4 | 0.91 | 0.49 | 100 | 49 | 14 | 100 | 1.95 | 0 |
GPR, gamma-glutamyl transpeptidase to platelet ratio index; APRI, aspartate transaminase to platelet ratio index; FIB-4, fibrosis index based on the 4 factors; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio. The GPR cut-offs obtained in HBV mono-infection patients in West Africa by Lemoine et al. were 0.32 for ≥ F2, 0.32 for ≥ F3, and 0.56 for = F4, respectively.