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. 2017 Mar 3;8(17):28865–28879. doi: 10.18632/oncotarget.15868

Figure 1. IDH1 R132H mutation increases chemosensitivity to TMZ.

Figure 1

(A) Cell colony formation assay was used to measure cell proliferation in IDH1, WT and NC overexpressing U87 cells and U251 cells. Quantification of cell proliferation is shown on the right. (B) Cell mobility difference was assessed using scratch test assay in U251 cells. Quantification of cell mobility is shown on the right. (C) IDH1 R132H, WT and NC overexpressing U87 cells and U251 cells were exposed to various concentrations of TMZ for 72 h, and cell viability was measured using MTT assay. All assays were performed in triplicate and representative images are shown. **P < 0.01 and ***P < 0.001 compared with NC and WT.