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. 2017 Mar 7;8(17):28922–28938. doi: 10.18632/oncotarget.15959

Figure 1. Inhibition of aerobic metabolism in SDHB knockout cancer cells.

Figure 1

(A) Cells were lysed 64 h after cell seeding, and expression levels of SDHB, SDHA, and β-actin were determined by western blotting. (B, C) Metabolite concentrations of fumarate, succinate, aspartate, malate, citrate, cis-aconitate, isocitrate, and α-ketoglutarate (α-KG) 48 and 96 h after cell seeding in HCT116 SDHB knockout cells (#7 and #23) compared with control cells, assessed using CE-MS (n = 3). Data are given as means ± standard deviation (SD). *P < 0.05, **P < 0.01, ***P < 0.001 by the Bonferroni's corrected t-test.