Table 2. Synergistic effects of SsaI and EGFR inhibitor.
| SsaI (μM) | AG1478 (μM) | CI* |
|---|---|---|
| 100 | 2.5 | 1.17 |
| 100 | 5 | 0.92 |
| 100 | 25 | 0.84 |
| 25 | 25 | 0.78 |
| 25 | 50 | 0.57 |
* Combination index (CI) is a quantitative measure of the degree of interaction between different drugs. If CI =1, it denotes additivity; if CI > 1, it denotes antagonism; and if CI < 1, it denotes synergism.