Table 2. Top 50 genes with positive coefficient toward advanced T stage, N stage, and perineural invasion.

log2. ratio ofcancer	T stagep-value	log2ratioof T stage	N stagep-value	log2ratio ofN stage	PNIp-value	log2ratio ofPNI	Multipleregressionp-value	Adjustedp-value	Gene symbol
1.405649235	0.005021	0.669221179	0.049282	0.414807777	0.0066929	0.577734589	8.67E-12	1.85E-09	CELSR1
0.902487966	0.017299	0.408004864	0.048754	0.274492969	0.0062699	0.388747711	8.01E-10	5.33E-08	PLXNA1
1.336755747	0.005524	0.878416145	0.010444	0.71439579	0.0018927	0.883976089	6.28E-08	1.46E-06	AHNAK2
0.774103937	0.000954	0.687681207	0.008804	0.45790676	0.0019398	0.569426772	5.74E-06	4.81E-05	LAMA5
0.568306702	0.015232	0.381576062	0.006886	0.351554572	0.0458663	0.278862871	7.42E-06	5.92E-05	RNF157-AS1
1.230802084	0.000229	1.183765995	0.005831	0.630328305	0.0271156	0.588247469	1.04E-05	7.72E-05	LOC728643
1.168560622	0.0305	0.781214914	0.00944	0.751484198	0.0016675	0.976805933	2.13E-05	0.000136725	TRIM29
1.593130487	0.042005	1.075298616	0.044852	0.915541975	0.0030054	1.328602148	4.05E-05	0.000229513	---
1.755681238	0.000359	1.952839198	0.006969	1.159846203	0.0261894	1.083681984	4.41E-05	0.000246188	CP
1.256035134	0.000343	1.382233559	0.035821	0.723628435	0.0001428	1.271430559	4.65E-05	0.000256884	CACNG4
1.035723885	0.038296	0.680393235	0.000894	0.891679109	0.0103758	0.719665669	6.05E-05	0.000319024	FOXJ1
1.055140967	0.000506	1.21563373	0.000779	0.910845838	0.00771	0.80855569	0.000163	0.000718317	ANXA8
0.38719036	0.003896	0.381130034	0.046294	0.235723632	0.0367647	0.267271458	0.000187	0.000805512	---
1.422747031	0.001163	1.680970054	0.011585	1.149656434	0.0004231	1.636415885	0.000259	0.001056886	SCEL
0.741694744	0.041854	0.500599655	0.017604	0.472999653	0.0090105	0.526894352	0.000303	0.001201835	IL20RB
1.048336388	0.000656	1.256426426	0.00088	0.948583195	0.0102444	0.816245506	0.000367	0.001407568	ANXA8L1
0.439815207	0.007863	0.420094066	0.015973	0.298972856	0.0468603	0.276542029	0.000405	0.001524813	PACSIN3
0.644644964	0.031368	0.510770319	0.011303	0.457911463	0.0238407	0.477635525	0.000432	0.001607237	NUP210
0.41460036	0.03709	0.311652312	0.016663	0.291643291	0.000777	0.41712347	0.000651	0.002251733	RARG
0.459884319	0.004722	0.493286574	0.045051	0.27407048	0.0322201	0.323656785	0.000967	0.003135081	MTSS1L
0.752843756	0.001219	0.926599211	0.00119	0.702989327	0.0191047	0.575784542	0.000974	0.003154055	ANXA8L2
0.326934803	0.006896	0.339485505	0.023013	0.24777875	0.0025399	0.325922534	0.001317	0.004059408	KCTD15
0.327674175	0.021866	0.313482341	0.019959	0.25034948	0.036247	0.266040443	0.001513	0.004559996	ZNF550
0.638509872	0.01561	0.628376088	0.027736	0.496854056	0.0167853	0.527506439	0.001932	0.005596862	03-Sep
0.641215401	0.002851	0.801735895	0.018654	0.562292769	0.0076319	0.66523785	0.002029	0.005824709	IGFBP3
0.499649263	0.042891	0.470272503	0.016633	0.459860135	0.0013724	0.619993877	0.005756	0.014050979	NMU
0.401188962	0.03306	0.405520149	0.026384	0.332817538	0.0409198	0.34779977	0.00705	0.016707122	RPGRIP1L
1.038620022	0.001477	1.622430348	0.01432	1.04114733	0.0001852	1.62939924	0.009159	0.020847277	MUC16
0.565775908	0.01136	0.736079957	0.019033	0.5676243	0.0199131	0.594558424	0.012178	0.026551104	---
0.375493033	0.042879	0.410540932	0.031223	0.373539325	0.001184	0.554925038	0.017506	0.036142137	SFTA2
0.375493033	0.042879	0.410540932	0.031223	0.373539325	0.001184	0.554925038	0.017506	0.036142137	SFTA2
0.187599817	0.024383	0.226129552	0.024041	0.187735793	0.0367099	0.179514001	0.019273	0.039199952	---
0.344763407	0.048564	0.379079767	0.027571	0.359760333	0.000962	0.530485462	0.021143	0.042354375	SFTA2
0.344763407	0.048564	0.379079767	0.027571	0.359760333	0.000962	0.530485462	0.021143	0.042354375	SFTA2
0.276170322	0.005814	0.433065399	0.008952	0.325178256	0.02379	0.303523881	0.02891	0.055235829	OBSL1
0.311893948	0.016383	0.456822732	0.02489	0.351506827	6.82E-05	0.62551085	0.029778	0.056617243	DUSP7
0.29107782	7.23E-05	0.680455719	0.031919	0.356012678	0.0002128	0.580257197	0.034151	0.063494817	SLC25A12
0.763158464	0.021464	1.089699767	0.000956	1.272277802	0.0286497	0.863378185	0.034747	0.064421874	CYP24A1
0.463353083	0.000208	1.071169232	0.002294	0.763081908	0.0003075	0.938569956	0.037331	0.068426105	PLAG1
0.235225211	0.006514	0.412864124	0.004589	0.359195411	0.0184164	0.333983417	0.037393	0.068520091	TBL1X
0.415837064	0.020375	0.618452648	0.003429	0.642991749	0.0031283	0.661698671	0.038076	0.069551285	TP63
0.36489978	3.79E-05	0.952535143	0.037331	0.445880795	0.000191	0.781545771	0.04198	0.075557211	PTPRU
0.221020043	0.001706	0.490176098	0.007407	0.367678885	0.0031479	0.422636582	0.064293	0.108164516	TMEM194B
0.211173621	4.11E-05	0.598084608	0.007149	0.316272465	0.0025179	0.417098103	0.067198	0.112310859	ZNF772
0.244788935	0.007511	0.460172837	0.049158	0.291772733	0.0001663	0.540728636	0.068464	0.114089313	CYP27C1
0.196298462	0.046793	0.290292197	0.034977	0.247751009	0.0459685	0.264254519	0.073753	0.121551209	ZNF211
0.189809559	2.48E-06	0.65798624	0.037054	0.257415442	0.000286	0.467404599	0.092093	0.146412737	SRGAP2B
0.46529506	0.013098	0.919444033	0.001183	0.98387549	0.0054371	0.850979956	0.10161	0.159071083	DSC3
0.336275552	0.048061	0.513851773	0.02283	0.482223223	0.0287236	0.459517938	0.111838	0.172326235	KRT4
0.432728625	0.043834	0.730488208	0.015057	0.717167303	0.0035367	0.883170907	0.116773	0.178647079	TRPV4