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. 2017 Mar 16;8(17):29091–29100. doi: 10.18632/oncotarget.16196

Figure 2. ShRNA-mediated knockdown of PHBP1 inhibits ESCC cells proliferation and tumor formation of ESCC cells.

Figure 2

Knockdown of PHBP1 in Eca9706 cells (A) and TE-1 cells (B) markedly reduced cell proliferation. Significant proliferation inhibition was observed after 3 days incubation (P<0.05). (C) Knockdown of PHBP1 show significant inhibitory effects on the colony formation of ESCC cell lines. The percentage of Eca9706 cells (D) and TE-1 cells (E) with stable knockdown of PHBP1 in S phase was significantly decreased, compared to negative control. (F and G) Tumor growth in nude mice subcutaneously injected into flanks with PHBP1-shRNA or negative control. Data are presented as means± SDs (n=8/group). The values was present as means ± SD. Statistical analyses were performed using One-way ANOVA or two-tailed Student's t-test, *P<0.05, compared with negative control.