Table 1. Clinical characteristics of HBV-related HCC patients.
| Variables | Patients(n=421) | No. of events (%) | MST(months) | HR (95% CI) | Log-rank P |
|---|---|---|---|---|---|
| Age (years) | 0.186 | ||||
| ≤60 | 367 | 162 (44.1) | 58 | 1 | |
| >60 | 54 | 25 (46.3) | 39 | 1.326 (0.869-2.025) | |
| Gender | 0.274 | ||||
| Male | 371 | 169 (45.6) | 51 | 1 | |
| Female | 50 | 18 (36.0) | 51 | 0.764 (0.470-1.243) | |
| Ethnicity | 0.978 | ||||
| Han | 259 | 117 (45.2) | 51 | 1 | |
| Minority | 162 | 70 (43.2) | 51 | 1.004 (0.746-1.353) | |
| BMI | 0.683 | ||||
| ≤25 | 332 | 145 (43.7) | 51 | 1 | |
| >25 | 89 | 42 (47.2) | 51 | 0.931 (0.659-1.315) | |
| Smoking status | 0.124 | ||||
| None | 272 | 115 (42.3) | 61 | 1 | |
| Ever | 149 | 72 (48.3) | 40 | 1.259 (0.937-1.692) | |
| Drinking status | 0.608 | ||||
| None | 255 | 109 (42.7) | 51 | 1 | |
| Ever | 166 | 78 (47.0) | 45 | 1.079 (0.806-1.443) | |
| Child–Pugh score | 0.006 | ||||
| A | 364 | 157 (43.1) | 58 | 1 | |
| B | 57 | 30 (52.6) | 34 | 1.718 (1.161-2.542) | |
| Cirrhosis | 0.225 | ||||
| No | 47 | 18 (38.3) | 88 | 1 | |
| Yes | 374 | 169 (45.2) | 51 | 1.348 (0.829-2.193) | |
| Radical resection& | 0.033 | ||||
| Yes | 240 | 96 (40.0) | 73 | 1 | |
| None | 171 | 86 (50.3) | 40 | 1.368 (1.023-1.831) | |
| Portal hypertension† | 0.595 | ||||
| No | 217 | 103 (47.5) | 57 | 1 | |
| Yes | 181 | 77 (42.5) | 45 | 1.084 (0.804-1.462) | |
| Pathological diagnosis‡ | 0.974 | ||||
| Well differentiated | 23 | 10 (43.5) | 47 | 1 | |
| Moderately differentiated | 323 | 143 (44.3) | 51 | 1.074 (0.565-2.040) | |
| Poorly differentiated | 12 | 5 (41.7) | 40 | 1.034 (0.353-3.027) | |
| Adjuvant antiviral treatment | 0.004 | ||||
| No | 271 | 146 (53.9) | 41 | 1 | |
| Yes | 150 | 41 (27.3) | NA | 0.605 (0.426-0.858) | |
| Tumor behavior | |||||
| Tumor size (cm) | <0.001 | ||||
| <10 | 316 | 126 (39.9) | 71 | 1 | |
| ≥10 | 105 | 61 (58.1) | 34 | 1.925 (1.414-2.621) | |
| Tumor number | <0.001 | ||||
| Single | 309 | 120 (38.8) | 61 | 1 | |
| Multiple | 112 | 67 (59.8) | 28 | 1.891 (1.401-2.551) | |
| Regional invasion | 0.068 | ||||
| Absence | 358 | 158 (44.1) | 58 | 1 | |
| Presence | 63 | 29 (46.0) | 40 | 1.445 (0.968-2.156) | |
| BCLC stage | <0.001 | ||||
| A | 250 | 81 (32.4) | 95 | 1 | |
| B | 69 | 40 (58.0) | 39 | 2.115 (1.447-3.091) | |
| C | 102 | 66 (64.7) | 25 | 3.216 (2.312-4.473) | |
| PVTT | <0.001 | ||||
| No | 352 | 138 (39.2) | 71 | 1 | |
| Yes | 69 | 49 (71.0) | 19 | 2.970 (2.135-4.131) | |
Notes: & Information of radical resection was unavailable in 10 patients; † Information of portal hypertension was unavailable in 23 patients; ‡ Information of pathological diagnosis was unavailable in 63 patients; BMI, body mass index; BCLC, Barcelona Clinic Liver Cancer; PVTT, portal vein tumor thrombus; MST, median survival time; HR, hazard ratio; CI, confidence interval.