Table 2. Genotype and haplotype distributions of PLCE1 at different serum AFP levels in HBV-related HCC patients.
| Variables | AFP (ng/ml) | Crude OR (95%CI) |
Crude P | Adjusted OR (95%CI) | Adjusted P§ | AFP (ng/ml) | Crude OR (95%CI) |
Crude P | Adjusted OR (95%CI) | Adjusted P§ | AFP (ng/ml) | Crude OR (95%CI) |
Crude P | Adjusted OR (95%CI) | Adjusted P§ | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| <20 | ≥20 | <200 | ≥200 | <400 | ≥400 | |||||||||||||
| Genotypes | ||||||||||||||||||
| rs2274223 | ||||||||||||||||||
| AA | 78 | 177 | 1 | 1 | 138 | 117 | 1 | 1 | 152 | 103 | 1 | 1 | ||||||
| AG | 35 | 102 | 1.284(0.805-2.049) | 0.294 | 1.357(0.833-2.210) | 0.22 | 63 | 74 | 1.385(0.913-2.101) | 0.125 | 1.424(0.922-2.198) | 0.111 | 70 | 67 | 1.412(0.930-2.146) | 0.105 | 1.427(0.922-2.209) | 0.111 |
| GG | 6 | 23 | 1.689(0.662-4.312) | 0.273 | 1.672(0.634-4.408) | 0.298 | 8 | 21 | 3.096(1.322-7.249) | 0.009 | 3.014(1.258-7.224) | 0.013 | 10 | 19 | 2.804(1.253-6.275) | 0.012 | 2.686(1.169-6.173) | 0.02 |
| AG+GG | 41 | 125 | 1.344(0.864-2.090) | 0.190 | 1.403(0.884-2.228) | 0.15 | 71 | 95 | 1.578(1.064-2.340) | 0.023 | 1.607(1.065-2.424) | 0.024 | 80 | 86 | 1.586(1.070-2.353) | 0.022 | 1.588(1.052-2.399) | 0.028 |
| rs3765524 | ||||||||||||||||||
| CC | 78 | 177 | 1 | 1 | 138 | 117 | 1 | 1 | 152 | 103 | 1 | 1 | ||||||
| CT | 35 | 102 | 1.284(0.805-2.049) | 0.294 | 1.357(0.833-2.210) | 0.22 | 63 | 74 | 1.385(0.913-2.101) | 0.125 | 1.424(0.922-2.198) | 0.111 | 70 | 67 | 1.412(0.930-2.146) | 0.105 | 1.427(0.922-2.209) | 0.111 |
| TT | 6 | 23 | 1.689(0.662-4.312) | 0.273 | 1.672(0.634-4.408) | 0.298 | 8 | 21 | 3.096(1.322-7.249) | 0.009 | 3.014(1.258-7.224) | 0.013 | 10 | 19 | 2.804(1.253-6.275) | 0.012 | 2.686(1.169-6.173) | 0.02 |
| CT+TT | 41 | 125 | 1.344(0.864-2.090) | 0.190 | 1.403(0.884-2.228) | 0.15 | 71 | 95 | 1.578(1.064-2.340) | 0.023 | 1.607(1.065-2.424) | 0.024 | 80 | 86 | 1.586(1.070-2.353) | 0.022 | 1.588(1.052-2.399) | 0.028 |
| Haplotypes | ||||||||||||||||||
| AC | 191 | 456 | 1 | 1 | 339 | 308 | 1 | 1 | 374 | 273 | 1 | 1 | ||||||
| GT | 47 | 148 | 1.319(0.912-1.908) | 0.142 | 1.352(0.922-1.983) | 0.123 | 79 | 116 | 1.616(1.168-2.237) | 0.004 | 1.629(1.164-2.281) | 0.004 | 90 | 105 | 1.598(1.158-2.205) | 0.004 | 1.592(1.140-2.224) | 0.006 |
Notes: § Adjustment for Child–Pugh score, tumor size, tumor number, BCLC stage, radical resection, regional invasion, adjuvant antiviral treatment, PVTT in logistic regression model; OR, odds ratio; CI, confidence interval.