Table 3. Association between risk factors and PLCE1 haplotypes in HBV-related HCC patients.
| Variables | AC(2n=842) | GT(2n=842) | OR (95%CI) | P |
|---|---|---|---|---|
| Tumor size(cm) | ||||
| ≤10 | 494 | 138 | 1 | |
| ≥10 | 153 | 57 | 1.334 (0.932-1.908) | 0.115 |
| Tumor number | ||||
| Single | 471 | 147 | 1 | |
| Multiple | 176 | 48 | 0.874 (0.604-1.264) | 0.474 |
| Child–Pugh score | ||||
| A | 548 | 180 | 1 | |
| B | 99 | 15 | 0.461 (0.261-0.814) | 0.008 |
| BCLC stage | ||||
| A | 380 | 120 | 1 | |
| B | 112 | 26 | 0.735 (0.458-1.180) | 0.203 |
| C | 155 | 49 | 1.001 (0.684-1.466) | 0.996 |
| Radical resection& | ||||
| Yes | 365 | 115 | 1 | |
| None | 264 | 78 | 0.938 (0.675-1.302) | 0.701 |
| Regional invasion | ||||
| Absence | 557 | 159 | 1 | |
| Presence | 90 | 36 | 1.401 (0.916-2.143) | 0.12 |
| PVTT | ||||
| No | 542 | 162 | 1 | |
| Yes | 105 | 33 | 1.051(0.685-1.614) | 0.818 |
| Pathological diagnosis‡ | ||||
| Well differentiated | 31 | 15 | 1 | |
| Moderately differentiated | 502 | 144 | 0.593 (0.311-1.128) | 0.111 |
| Poorly differentiated | 19 | 5 | 0.544 (0.170-1.739) | 0.304 |
Notes: & Information of radical resection was unavailable in 10 patients; ‡ Information of pathological diagnosis was unavailable in 63 patients; OR, odds ratio; CI, confidence interval; BCLC, Barcelona Clinic Liver Cancer stage; PVTT, portal vein tumor thrombus.