Table 4. Survival analysis of HBV-related HCC patients according to PLCE1 haplotype and serum AFP level.
| Variables | Patients (n=421) | No. of events (%) | MST (months) | Crude HR(95% CI) | Crude P | Adjusted HR(95% CI) | Adjusted P§ |
|---|---|---|---|---|---|---|---|
| Haplotypes ψ | |||||||
| AC | 647 | 283 (46.9) | 57 | 1 | 1 | ||
| GT | 195 | 91 (49.5) | 42 | 1.096 (0.865-1.388) | 0.449 | 1.143 (0.900-1.452) | 0.272 |
| AFP (ng/mL) | |||||||
| Cut-off in 20 | |||||||
| <20 | 119 | 40 (33.6) | 71 | 1 | 1 | ||
| ≥20 | 302 | 147 (48.7) | 41 | 1.683 (1.186-2.388) | 0.004 | 1.276 (0.887-1.836) | 0.19 |
| Cut-off in 200 | |||||||
| <200 | 209 | 86 (41.1) | 58 | 1 | 1 | ||
| ≥200 | 212 | 101 (47.6) | 43 | 1.238 (0.928-1.652) | 0.146 | 0.938 (0.692-1.272) | 0.682 |
| Cut-off in 400 | |||||||
| <400 | 232 | 96 (41.4) | 58 | 1 | 1 | ||
| ≥400 | 189 | 91 (48.1) | 43 | 1.262 (0.947-1.683) | 0.112 | 0.985 (0.727-1.335) | 0.923 |
Notes: ψ The number of heplotypes was 2n (2n=842); § Adjustment for Child–Pugh score, tumor size, tumor number, BCLC stage, radical resection, regional invasion, adjuvant antiviral treatment, PVTT in Cox proportional hazards regression model; MST, median survival time; HR, hazard ratio; CI, confidence interval.