Table 2. Association between antiestrogens use and incidence of cervical neoplasia in the breast cancer cohort.
5 year follow-up | 10 year follow-up | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Low-grade dysplasia | High-grade dysplasia | High-grade dysplasia | ICC | |||||||||
Nonuser | AI-included | Tamoxifen only | Nonuser | AI-included | Tamoxifen only | Nonuser | AI-included | Tamoxifen only | Nonuser | AI-included | Tamoxifen only | |
No. of patients | 15136 | 7516 | 19761 | 15076 | 7510 | 19660 | 14893 | 8084 | 19018 | 14843 | 8064 | 18935 |
Patients with event | 113 | 33 | 200 | 53 | 27 | 99 | 63 | 30 | 103 | 13 | 10 | 20 |
Person-years | 49154 | 26953 | 66633 | 49095 | 26942 | 66415 | 60919 | 38091 | 79764 | 60780 | 38025 | 79610 |
Incidence per 105person-years | 230 | 122 | 300 | 108 | 100 | 149 | 103 | 79 | 129 | 21 | 26 | 25 |
95% CI | 191-276 | 86.8-172 | 261-344 | 82-141 | 68-146 | 122-181 | 80-132 | 55-112 | 106-156 | 12-36 | 14-48 | 16-38 |
HR: hazard ratio;
aModel adjusted for age, Pap smear density and chemotherapy