Figure 2. Circulating Th22 cells, a principal source of intracellular IL-22 in peripheral blood.

A. The cells were gated initially on IL-22⁺ cells and then on CD4⁺T cells and IL-17A cells. B. Circulating IL-22⁺IL-17A⁻CD4⁺Th22 (cTh22) cells. C. Circulating IL-22⁺cTh17 cells. D. IL-17A⁻CD4⁻cells in the total IL-22⁺ cells were analyzed in HC and mild and severe patients. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ns, no significant difference