Table 1. Clinical characteristics of 56 recruited cases with EV71-associated HFMD.
| Group | Age (Months) | Gender (M/F) | Hospitalized days | Fever (>37.5◦C) | Rash | Laboratory results | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| WBC (×109/L) | CRP (mg/L) | CK-MB (U/L) | AST (mmol/L) | LDH (U/L) | Viral Titer (Ct value) | ||||||
| HC | 39.5±18.7 | 26/20 | no | no | no | 6.42±0.91 | 0.15±0.10 | 19.95±3.73 | 26.75±6.25 | 275.19±56.85 | no |
| Mild | 30.3±16.8 | 18/14 | 5.0±1.4 | 31 (96.9%) | 32(100%) | 9.74±3.28 | 6.87±3.37 | 41.94±11.96 | 36.87±8.69 | 326.31±68.15 | 25.65±4.62 |
| Severe | 23.3±9.8 | 13/11 | 16.7±4.1 | 24 (100%) | 24 (100%) | 13.62±5.38 | 8.79±4.66 | 40.58±9.84 | 37.58±11.22 | 374.87±94.71 | 25.87±4.36 |
Note: data correspond to the arithmetic mean±SD. M/F: male/female; WBC: White blood cell; CRP: C-reactive protein; CK-MB: Creatine kinase-MB; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDH: Lactate dehydrogenase; HC: healthy controls; Ct: Cycle threshold. The Ct value defines as the number of cycles required for the fluorescent signal to cross the detection threshold, the low Ct value represents high viral titer, and high Ct value represents low viral titer. 56 Laboratory-confirmed HFMD children caused by EV71 infection were enrolled and classified into two groups depending on the clinical severity of disease and degrees of neurological damage.