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. 2017 Feb 11;8(17):29474–29486. doi: 10.18632/oncotarget.15298

Table 1. Study on correlation of sun exposure and gastric cancer.

Study design Study period
/Participants
Vitamin D index Outcome Summary of findings References
(year, country)
Ecologic study 1970-1994 TOMS DNA-weighted UVB Mortality of premature gastric cancer Inverse correlation
P < 0.001
Grant et al.
(2002, US)
Ecologic study 1961-1990 Average annual hours of solar radiation Mortality of gastric cancer Inverse correlation
P < 0.001
Mizoue
(2004, Japan)
Ecologic study 1993-2002 Latitude and Annual erythemally weighted UVB Mortality and incidence of gastric cancer Inverse correlation
P < 0.001
Boscoe et al.
(2006, US)
Ecologic study 1990-1994 Latitude and
dietary supply factors
Mortality and incidence of gastric cancer Inverse correlation
P < 0.05
Grant et al.
(2006, western
European)
Ecologic study 1970-1994 TOMS DNA-weighted UVB Mortality of gastric cancer Inverse correlation
P < 0.001
Grant et al.
(2006, US)
Ecologic study 1978-1992 Latitude, skin cancer and melanoma Mortality of gastric cancer Inverse correlation
p < 0.01
Grant et al.
(2007, Spain)
Case-control 416,134 cases
3,776,501controls
Skin cancer and sunexposure Incidence of gastric cancer Inverse correlation
SIR: 0.65
95%CI:0.45–0.91
Tuohimaa et al.
(2007, Five Continents)
Ecologic study 1950-1994 TOMS DNA-weighted UVB Mortality of gastric cancer Inverse correlation
p < 0.001
Grant et al.
(2010, US)
Ecologic study 1998–2002 UVB from NASA database and GIS methods Mortality of gastric cancer Inverse correlation
p < 0.001
Chen et al.
(2010, China)
Nested case-control 115,016 cases
987,893controls
Skin cancer Incidence of gastric cancer No correlation
OR:1.00
95%CI:0.85–1.17
Lindelof et al.
(2012, Swedish)
Ecologic study 2000-2002 UVB intensity from NASA database and spatial Kriging method Mortality of gastric cancer Inverse correlation
HR:0.89
95%CI:0.83-0.95
Chen et al.
(2013, China)