Table 1A. Overview of fatty acid metabolism gene mRNA expression in breast cancer.
| TNBC relative to RPBC | ||||||
|---|---|---|---|---|---|---|
| CHANGE (P<0.05) | CHANGE (NS) | NO. of STUDIES | ||||
| ↑ | ↓ | ↑ | ↓ | |||
| GENE | ||||||
| FUNCTION | ||||||
| Synthesis | ACLY | 0 | 9 | 3 | 9 | 21 |
| ACACA | 0 | 13 | 2 | 6 | 21 | |
| FASN | 0 | 14 | 3 | 4 | 21 | |
| SCD1 | 0 | 12 | 0 | 9 | 21 | |
| SREBP1 | 0 | 19 | 0 | 2 | 21 | |
| Transport | VLDLR | 15 | 0 | 4 | 1 | 20 |
| LPL | 10 | 0 | 8 | 3 | 21 | |
| FABP5 | 18 | 0 | 2 | 1 | 21 | |
| FABP7 | 15 | 0 | 5 | 1 | 21 | |
| Activation | ACSL3 | 1 | 14 | 1 | 4 | 20 |
| ACSL4 | 15 | 0 | 5 | 1 | 21 | |
| SLC27A2 | 0 | 17 | 1 | 2 | 21 | |
| Storage | PLIN2 | 18 | 0 | 2 | 1 | 21 |
| PLIN5 | 0 | 8 | 0 | 5 | 13 | |
| LPIN1 | 19 | 0 | 1 | 1 | 21 | |
| Mobilization | MMGL | 0 | 14 | 2 | 5 | 21 |
| PNPLA2 | 1 | 11 | 3 | 6 | 21 | |
| PLA2G4A | 16 | 0 | 4 | 1 | 21 | |
| Oxidation | CPT1A | 1 | 16 | 1 | 3 | 21 |
| ACOX2 | 0 | 20 | 1 | 0 | 21 | |
| Uptake of | ||||||
| Glucose | SLC2A1 | 11 | 1 | 8 | 1 | 21 |
| Glutamine | SLC6A14 | 15 | 0 | 1 | 2 | 18 |
Data taken from Oncomine [9].