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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Hear Res. 2016 Dec 26;349:182–196. doi: 10.1016/j.heares.2016.12.011

Fig. 4.

Fig. 4

Possible epigenetic regulatory mechanisms during HC regeneration. The compact chromatin structure becomes accessible to transcriptional mechanisms by histone modification, including methylation (Me) and acetylation (Ac), and chromatin remodeler binding. Pioneer TFs are able to interact with the condensed DNA and facilitate the targeting of other TFs. DNA methylation also controls the initiation of transcription.