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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Am Soc Mass Spectrom. 2017 Jan 3;28(6):991–1004. doi: 10.1007/s13361-016-1554-2

Figure 2.

Figure 2

Oxidation of an intermolecularly disulfide-linked peptide generated from a peptic digest of insulin. CID of (a) the ion/ion complex between doubly protonated NYCN/LVCGERGFF and IO4−, and (b) CID of the oxidized species. The sequence of the peptide is shown inset in (a) along with the structure of the [M+H+O]+ species. Structures of the [B+H+S+O]+, [B+H+O]+, [B-H]+, and [B-H-S]+ species are shown in (b). Fragments derived from cleavage of the disulfide bond are indicated in blue as all fragments observed correspond to fragments from the B-chain (indicated in blue in inset). Lightning bolts indicate species subjected to CID and degree signs indicate water losses.