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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Hear Res. 2017 Jan 10;349:138–147. doi: 10.1016/j.heares.2017.01.003

Fig. 5. Gradients in synaptic and afferent fiber morphology.

Fig. 5

IHC synapses in confocal z-stacks, acquired in the x-y plane (A) and re-projected into the y-z (B) plane. A Pre- and post-synaptic elements in the IHC area are counted in cochlear whole mounts quadruple-immunostained for CtBP2 (red), GluA2 (green), NaK ATPase (blue), and myosin VIIa (white). B Size gradients in pre- and post-synaptic elements are quantified according to location along habenular-cuticular and modiolar-pillar axes (Liberman et al., 2015). (C) Tracing of peripheral axons from a cross section through the osseous spiral lamina (OSL; D) in a normal cat shows the SR-based gradient from thin (low-SR) to thick (high-SR) fibers (Kawase and Liberman, 1992).