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. 2017 May 7;2017:3679295. doi: 10.1155/2017/3679295

Figure 5.

Figure 5

A schematic representation of the effects and the principle molecular mechanisms of TJ-20 on adjuvant arthritis. TJ-20 reduces the recruitment of macrophages and helper T cells into the synovia of ankle joint in AA rats. Consequently, TJ-20 downregulates the production of TNF-α but augments the production of IL-10, which are mainly released by macrophages; TJ-20 also regulates the balance of Th1/Th2 ratio as it suppresses a recruitment of Th1 cells in the synovia of AA rats.