Table 2.
Effects of TJ-20 on Thl/Th2 balance in the synovia of ankle joint in AA rats.
| Time | AA rats | AA rats treated with TJ-20 | ||||
|---|---|---|---|---|---|---|
| CXCR3 (Th1) |
CCR4 (Th2) |
CXCR3/CCR4 Th1/Th2 ratio |
CXCR3 (Th1) |
CCR4 (Th2) |
CXCR3/CCR4 Th1/Th2 ratio |
|
| 2 weeks | 60 ± 6.5 | 27 ± 4.3 | 2.22 | 46.9 ± 5.2∗∗ | 29.8 ± 4.2 | 1.57 |
| 3 weeks | 52 ± 5.7 | 44 ± 7.2 | 1.18 | 43.1 ± 6.1∗ | 44.6 ± 3.8 | 0.97 |
| 4 weeks | 42 ± 4.8 | 56 ± 6.7 | 0.75 | 38 ± 3.6 | 61.6 ± 3.1 | 0.62 |
By use of doubled-immunofluorescence study, we have determined the percentages of CXCR3/W3/25-double-positive cells and CCR4/W3/25-double-positive cells among total W3/25-positive cells in AA rats and AA rats with TJ-20 administration from day 7 after adjuvant injection. Data are the mean ± SD for 6 rats in each group. Asterisks indicate a statistically significant difference from AA rats (∗P < 0.05, ∗∗P < 0.01).