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Rac1/Cdc42 and RhoA are both required for neural tube closure. Schematic representation of the roles of Rho GTPases during spinal neurulation. Rac1/Cdc42 are required in the SE for the formation of protrusions that initiate contacts with contralateral SE cells. RhoA is essential in the NE, where it regulates the balance of assembly and disassembly of actomyosin. F-actin is depicted in red.
