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. Author manuscript; available in PMC: 2017 Jul 28.
Published in final edited form as: Oncogene. 2016 Nov 21;36(30):4235–4242. doi: 10.1038/onc.2016.394

Figure 3. Enhanced MEKK4-p38-Noxa pathway in basal-type breast cancer cells contributes to cystine-deprived necrosis.

Figure 3

(A). Immunoblotting of indicated proteins in a panel of luminal or basal type breast cancer cells.

(B). Cell cytotoxicity and survival of BT549 infected with shScr and two different shMEKK4 under indicated levels of cystine for 24 hours (n=4, p < 0.01).

(C). Immunoblotting of MEKK4, MKK3/6 phosphorylation and p38 phosphorylation in BT549 with shScr and shMEKK4 under high (HC, 200 μM) or low cystine (LC, 1 μM) for 18 hours.