Fig. 3. (A) Significantly higher proportion of excessive collagen bundle deposition (57.1% vs. 7.1%, p=0.013). (B) Diffuse periostin expression (42.9% vs. 0%, p=0.016) in the localized scleroderma specimens compared to controls. (C) Moderate matrix metalloproteinase (MMP)-1 expression (71.4% vs. 7.1%, p=0.001) in the localized scleroderma specimens compared to controls. ^*p<0.05, ^**p<0.01.