Figure 6.

Hypothetical schematic representation of conformational changes of Aβ 1–42 along ozone exposure. In the first stage, there is an abundance of the α-helix conformation. After 30 days of ozone exposure, in a second stage, there is a mixture of α-helix, β-turn and random coil motifs. After 90 days of ozone exposure, the third stage, there is a majority of β-sheet secondary structure conformation. This trend is related with the increase toxicity of ozone and the neurodegeneration progress in the hippocampus of rats. Model figures 1Z0Q, 2OTK and 2BEG, taken from the PDB files.