Table 1.

A summary of low-density lipoprotein receptor-related protein-1 (LRP1)-regulated angiogenic pathways.

Pathway	Study system	Angiogenic phenotype	Reference
Bone morphogenetic protein	Morpholino knockdown in zebrafish	Fewer ventral sprouting events, dorsal and intersegmental vessel malformation, fewer vascular branches	(7)
PARP-1	Tie2-Cre in mice	Increased retinal neovascularization, increased endothelial proliferation	(5)
Sphingosine-1-phosphate	Meox2-Cre in mice	Interrupted endothelial integrity, embryos with extensive hemorrhage	(6)
Urokinase-type plasminogen activator (uPA)	LRP1 Ab and antagonist-receptor-associated protein (RAP) in PMVECs	Inhibition of uPA-induced vascular permeability	(32)
VEGF	Antagonist RAP in HUVEC	Inhibition of VEGF-induced endothelial migration, proliferation, and permeability	(33)