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. 2017 May 22;10:148. doi: 10.3389/fnmol.2017.00148

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Copyright © 2017 Bartholome, Van den Ackerveken, Sánchez Gil, de la Brassinne Bonardeaux, Leprince, Franzen and Rogister.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interaction model of SV2A and Stonin 2 with Synaptotagmin 1. (A) After fusion event, the C2B domain of Synaptotagmin 1 (green) interacts with SV2A (light blue) phosphorylated-T84 residue (orange) and Stonin 2 (dark blue) binds to both C2 domains of Synaptotagmin to initiate recycling. (B) SV2A and Stonin 2 bind to AP-2 (pink) to facilitate the formation of the endocytosis complex. (C) Synaptotagmin 1 binds to AP-2. Dephosphorylated SV2A keeps interaction with AP-2 to consolidate the endocytosis complex. (D) After endocytosis, the fusion competent vesicle presents Synaptotagmin 1 bond again to T84-phosphorylated SV2A. IC, Intracellular; EC, Extracellular.