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. 2017 May 22;8:266. doi: 10.3389/fphar.2017.00266

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Copyright © 2017 Wang, Ma, Guo, Sun, Liu, Zhu, Liu, Li, Li, Chen, Sun, Tang, Zhao, Mo, Niu, Jiang, Fu, Brömme, Zhang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The representative western blot images and their analysis showed that FLL treatment decreased IκBα and p-IκBα expression in the tibias (A) and uteri (B) of OVX rats (n = 9). In addition, confocal microcopy of immunofluorescence staining (C; original magnification, × 60) showed that FLL blocked NF-κB-p65 nuclear translocation in the femurs of OVX rats. The green color represents NF-κB-p65 staining, the blue color represents nuclei staining, and the cyan (greenish-blue) color represents nuclear translocation. ^#p < 0.05 with Sham group, *p < 0.05 compared with OVX group.