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. 2017 May 22;8:266. doi: 10.3389/fphar.2017.00266

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Copyright © 2017 Wang, Ma, Guo, Sun, Liu, Zhu, Liu, Li, Li, Chen, Sun, Tang, Zhao, Mo, Niu, Jiang, Fu, Brömme, Zhang and Gao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The representative images of immunohistochemical staining (A–D; sections were counterstained with hematoxylin; original magnification, × 20), and western blot assays (E,F) showed that FLL treatment decreased Nox4 expression in tibias and uteri of OVX rats (n = 9). In addition, FLL treatment also decreased cytochrome C (Cyto-C; G) and increased Bcl-2 expression (H) in the tibias of OVX rats (n = 9). Data are presented as mean ± SD. IOD denotes integrated optical density of interested areas. ^#p < 0.05 with Sham group, *p < 0.05 compared with OVX group.