Table 3.

Interactions by molecular docking of indomethacin, memantine and compounds identified in FAc with COX-2, GluN1a and GluN2B.

GluN1a			GluN2B			COX-2
Ligand	ΔGbind* (kcal/mol)	Ki** (μM)	Ligand	ΔGbind* (kcal/mol)	Ki ** (μM)	Ligand	ΔGbind* (kcal/mol)	Ki** (μM)
Memantine	−7.82	1.86	Memantine	−5.66	71.18	Indomethacin	−8.30	0.82
Ursolic acid	−7.02	7.13	Ursolic acid	−5.69	67.35	Ursolic acid	−9.86	0.05
Ellagic acid	−5.67	70.17	Ellagic acid	−5.34	122.58	Ellagic acid	−7.54	2.99
Gallic acid	−4.57	448.26	Gallic acid	−5.16	164.28	Gallic acid	−6.68	12.69
Caffei acid	−4.47	531.44	Caffei acid	−5.04	201.80	Caffei acid	−5.88	49.19

^*ΔG_bind, binding energy.

^**Ki, inhibition constant.