Table 4.

Interactions of ursolic acid, memantine and indomethacin for the conformations chosen by molecular docking.

GluN1a			GluN2B		COX-2
Ligand	Hydrogen bonds	Hydrophobic interactions	Hydrogen bonds	Hydrophobic interactions	Hydrogen bonds	Hydrophobic interactions
Ursolic acid	Tyr535, Arg733	Ile497, Phe507, Ser508, Lys509, Pro510, Ser734, Gly735	Phe493, Lys736	Ile483, Ser420, Glu489, Val491, Asp492	Lys83, Tyr122, Ser471	Pro84, Tyr115, Ser119, Arg120, Leu123, Phe470, Glu524, Pro528
Memantine	Asp765, Asp767	Lys512, Ala712, Glu715, Phe716, Glu764	Val490	Val169, Trp171, Glu489, Lys736, Asp737	NA	NA
Indomethacin	NA	NA	NA	NA	Lys83, Tyr122	Asn43, Arg44, Thr62, Leu80, Lys468, Arg469, Ser471.

NA, Not rated.