Table 2.
Factors Associated with LCI at the Enrollment Visit
| Health |
CF |
|||
|---|---|---|---|---|
| n | LCI units/year (95% Confidence Interval) | n | LCI units/year (95% Confidence Interval) | |
| First visit | ||||
| Age | 70 | −0.01 (−0.11 to 0.10) | 78 | 0.58 (0.13 to 1.03) |
| Height-for-age z score | 70 | 0.05 (−0.07 to 0.17) | 78 | −0.39 (−0.87 to 0.08) |
| Weight-for-age z score | 70 | 0.02 (−0.12 to 0.15) | 78 | −0.31 (−0.81 to 0.19) |
| BMI-for-age z score | 70 | −0.02 (−0.14 to 0.11) | 78 | 0.02 (−0.51 to 0.55) |
| Sex | ||||
| Male | 32 | Reference | 39 | Reference |
| Female | 38 | −0.10 (−0.35 to 0.14) | 39 | 0.12 (−0.79 to 1.02) |
| Ethnicity | ||||
| White | 53 | Reference | 69 | Reference |
| Other | 17 | −0.10 (−0.35 to 0.14) | 9 | −0.85 (−2.25 to 0.55) |
| Newborn screening | ||||
| No | 16 | Reference | ||
| Yes | 62 | 0.77 (−0.34 to 1.87) | ||
| Mutation class | ||||
| I–III | 75 | Reference | ||
| IV–V* | 3 | −2.34 (−4.63 to −0.05) | ||
| Pancreatic sufficient* | 5 | Reference | ||
| Pancreatic insufficient | 73 | 1.14 (−0.68 to 2.97) | ||
| Hospitalization history | ||||
| 0 hospitalizations | 48 | Reference | ||
| 1 hospitalizations | 13 | 0.92 (−0.21 to 2.1) | ||
| 2 hospitalization | 10 | 1.9 (0.62 to 3.13) | ||
| 3+ hospitalization | 7 | 2.6 (1.09 to 4.02) | ||
| Microbiology history | ||||
| Pseudomonas aeruginosa | 46 | 0.90 (0.00 to 1.79) | ||
| Staphylococcus aureus | 54 | 1.44 (0.14 to 2.76) | ||
| Methicillin-resistant S. aureus | 11 | −0.001 (−1.30 to 1.30) | ||
| Stenotrophomonas maltophilia | 16 | 0.31 (−0.81 to 1.42) | ||
| Haemophilus influenzae | 40 | −0.38 (−1.29 to 0.51) | ||
| Burkholderia cepacia complex† | 2 | 3.61 (0.87 to 6.35) | ||
| Aspergillus fumigatus | 2 | 1.07 (−1.78 to 3.92) | ||
| Treatment history | ||||
| Hypertonic saline | 34 | 0.69 (−0.20 to 1.59) | ||
| Dornase alfa | 29 | 0.52 (−0.41 to 1.44) | ||
| Chronic inhaled antibiotic therapy | 14 | 1.39 (0.26 to 2.52) | ||
Definition of abbreviations: BMI = body mass index; CF = cystic fibrosis; LCI = Lung Clearance Index.
Coefficients are derived from a univariable linear regression analysis and represent the slope (LCI units/yr) (95% confidence interval). A positive coefficient indicates higher (worse) LCI, whereas a negative coefficient represents lower (better) LCI. Values are bold if the estimate is significantly different from 0 at the P < 0.05 significance level.
*
Based on three observations in this category.
†
Based on two observations in this category.