FIGURE 8.

Ams, but not ATII cells, from AIM2-deficient mice exhibit an impairment in IL-1β response post IAV infection. ATII cells and AMs isolated from WT and AIM2^−/− mice were infected with PR8 at an moi of 1. At 24 hpi, RNA was harvested from cells for evaluation of IL-1β gene expression by real-time RT-PCR, and culture supernatants were collected for detection of IL-1β using Bio-Plex IL-1β singleplex set (BioRad) following manufacturer’s protocol. (A) ATII cells. (B) AMs. Data represent results from one of three experiments.