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. 2017 Jul;103:11–23. doi: 10.1016/j.nbd.2017.03.012

Fig. 2.

Fig. 2.

Long-term effect of treatment with ELN on the size of the population of neural precursor cells in the dentate gyrus. A: Examples of sections processed for fluorescent immunostaining for Ki-67 from the dentate gyrus of untreated euploid and Ts65Dn mice and euploid and Ts65Dn mice treated with ELN. Examples of Ki-67-positive cells are indicated by the arrowheads. Calibrations = 200 μm (lower magnification) and 40 μm (higher magnification). B, C: Mean number of Ki-67-positive cells per section (B) and total number of Ki-67-positive cells (C) in the DG of treated and untreated Ts65Dn and euploid mice (n = 6 for each experimental group). Values represent mean ± SE. *p < 0.05; ***p < 0.001 (Fisher LSD test). White asterisks in the black bar indicate a difference between treated Ts65Dn mice and treated euploid mice. Abbreviations: ELN, ELND006; Eu, Euploid; Gr, granule cell layer; SGZ, subgranular zone.