Fig. 5.

Long-term effect of treatment with ELN on protein levels. Western blot analysis of Ptch1 and p21 in the hippocampus of treated and untreated Ts65Dn and euploid mice (n = 8 for each experimental group). A-D: Examples of western blot images of Ptch1 (B) and p21 (D) and quantification of Ptch1 (A) and p21 (C) levels normalized to GAPDH. Values (mean ± SE) are expressed as fold difference in comparison with untreated euploid mice. (*)p < 0.06; *p < 0.05; **p < 0.01 (Fisher LSD). Abbreviations: ELN, ELND006; Eu, Euploid.