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. 2017 Jul;103:11–23. doi: 10.1016/j.nbd.2017.03.012

Fig. 6.

Fig. 6.

Long-term effect of treatment with ELN on hippocampal synapses in Ts65Dn and euploid mice. A-D: Images in the panels at the top represent confocal microscope images of sections processed for SYN (A, C) and PSD-95 (B,D) immunofluorescence from the molecular layer of the DG (A, B) and the stratum lucidum of field CA3 (C, D) of an animal from each experimental group. Calibration = 5 μm. The histograms represent the number of puncta per μm2 exhibiting SYN (A, C) and PSD-95 (B, D) immunoreactivity in the molecular layer of the DG (A, B) and the stratum lucidum of CA3 (C, D) of treated and untreated Ts65Dn and euploid mice (n = 6 for each experimental group). Values represent mean ± SE *p < 0.05; **p < 0.01; ***p < 0.001 (Fisher LSD test). Black asterisks in the gray bar indicate a difference between untreated Ts65Dn mice and treated euploid mice; white asterisks in the black bar indicate a difference between treated Ts65Dn mice and treated euploid mice. Abbreviations: ELN, ELND006; Eu, Euploid.