Table 4:
Association between CYP17 MspA1 polymorphism and potential BC risk factors such as laterality, type of breast cancer, family history of cancer and menarche age
| Variables | Patients Under 40 | Patients over 40 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Combined genotype A1/A2 & A2/A2 n (%) | Genotype A1/A1 n (%) | OR | 95%CI | P value | Combined genotype A1/A2 & A2/A2 n (%) | Genotype A1/A1 n (%) | OR | 95%CI | P value | |
| Unilateral | 71 (71) | 29 (29) | 0 | 0 | 0.998 | 51 (56) | 40 (44) | 0.348 | 0.069– | 0.203 |
| Bilateral | 4 (100) | 0 (0) | 7 (77.8) | 2 (22.2) | 1.769 | |||||
| Invasive ductal carcinoma | 47 (79.7) | 12 (20.3) | 2.848 | 0.939- | 0.064 | 30 (50.8) | 29 (49.2) | 0.796 | 0.302- | 0.644 |
| Other types | 8 (42.1) | 11 (57.9) | 8.640 | 14 (60.9) | 9 (39.1) | 2.098 | ||||
| Family history of cancer | 37 (69.8) | 16 (30.2) | 0.791 | 0.335- | 0.594 | 38 (63.3) | 22 (36.7) | 2 | 0.892- | 0.093 |
| No family history of | 38 (74.5) | 13 (25.5) | 1.871 | 20 (48.8) | 21 (51.2) | 4.486 | ||||
| cancer | ||||||||||
| Menarche age under 12 | 14 (56) | 11 (44) | 0.35 | 0.124- | 0.047 | 9 (50) | 9 (50) | 0.963 | 0.330- | 0.945 |
| Menarche age 12 or over | 40 (78.4) | 11 (21.6) | 0.984 | 28 (52.8) | 25 (47.2) | 2.806 | ||||