Table 3.
Comparison between nonsurvivors and survivors. Data are presented as patient number (%) and mean (SD) or medians (interquartile range) as appropriate.
| Nonsurvivors (n = 4) | Survivors (n = 16) | p value | |
|---|---|---|---|
| Age, year, mean (SD) | 76.2 (2.1) | 58.7 (13.3) | 0.0196 |
| Male, number (%) | 0 (0%) | 8 (50%) | 0.068 |
| APACHE II, mean (SD) | 22.2 (5.0) | 18.2 (3.8) | 0.093 |
| SAPS II, mean (SD) | 40.0 (9.8) | 36.7 (7.8) | 0.486 |
| Underlying diseases, number (%) | |||
| Renal transplantation | 0 (0%) | 7 (43.7%) | 0.101 |
| Rheumatoid Arthritis | 3 (75%) | 4 (25%) | 0.061 |
| Interstitial lung disease | 2 (50%) | 1 (6.2%) | 0.028 |
| PED (mg), median (range) | 7.0 (5.3, 9.8) | 6.4 (5.0, 12.0) | 0.528 |
| Methotrexate use (mg), median (range) | 6.0 (3.0, 10.0) | 0.0 (0.0, 0.6) | 0.088 |
| Duration before treat (days), median (range) | 1.5 (0.8, 4.0) | 4.0 (1.8, 7.0) | 0.629 |
| Duration before ARF (days), median (range) | 1.5 (0.8, 4.0) | 4.0 (2.0, 7.0) | 0.565 |
| WBC (/µL), mean (SD) | 7992.5 (1734.4) | 9862.5 (3523.5) | 0.323 |
| Albumin (g/dL), mean (SD) | 2.3 (0.5) | 2.9 (0.4) | 0.027 |
| β-D-Glucan (pg/mL), mean (SD) | 67.7 (70.6) | 1158.9 (1448.2) | 0.157 |
| LDH (U/L), mean (SD) | 424.2 (59.6) | 511.3 (211.5) | 0.434 |
| KL-6 (U/mL), mean (SD) | 2700.3 (1673.1) | 738.7 (566.6) | 0.002 |
| SP-D (ng/mL), mean (SD) | 1433.3 (1968.3) | 220.3 (168.5) | 0.042 |
| Worst P/F (mmHg), mean (SD) | 145.5 (52.2) | 171.3 (65.1) | 0.475 |
| PaCO2 on admission (mmHg), mean (SD) | 27.5 (5.2) | 27.6 (4.8) | 0.968 |
| Tracheal intubation, number (%) | 4 (100%) | 8 (44%) | 0.245 |
| Mechanical ventilation | |||
| PEEP day 1 (cmH2O), median (range) | 10.0 (9.5, 10.0) | 9.0 (7.8, 12.0) | 0.668 |
| PEEP day 3 (cmH2O), median (range) | 10.0 (9.5, 13.0) | 10.0 (8.0, 14.3) | 0.615 |
| PEEP day 5 (cmH2O), median (range) | 10.0 (9.5, 12.5) | 10.0 (8.0, 14.0) | 0.711 |
| NPPV duration, days, median (range) | 5.5 (1.0, 10.3) | 3.5 (1.0, 6.8) | 0.663 |
| Days of intubation, days, median (range) | 26.0 (18.3, 31.8) | 2.5 (0.0, 9.3) | 0.077 |
| Days of ventilation, days, median (range) | 32.5 (26.0, 36.0) | 7.5 (5.0, 12.3) | 0.068 |
| Pulse therapy of methylprednisolone, number (%) | 3 (75.0%) | 6 (37.5%) | 0.177 |
| Length of hospitalization (days), median (range) | 39.5 (35.8, 57.8) | 29.5 (24.0, 57.3) | 0.844 |
Definition of Abbreviations. APACHE, acute physiological and chronic health evaluation, SAPS; simplified acute physiological score, PED; prednisolone-equivalent dose, ARF; acute respiratory failure, WBC; white blood cell, LDH; lactate dehydrogenase, SP-D; surfactant protein-D, P/F; PaO2/FIO2, PEEP; positive end-expiratory pressure, NPPV; noninvasive positive pressure ventilation.