Table 2.
IC50 and Ki values (µM) for naringenin, quercetin, and sesamin calculated for mice from the unexposed, low-exposed, and high-exposed groups.
| Enzyme | Phytochemical | Level of exposure | P value | ||
|---|---|---|---|---|---|
| Unexposed | Low | High | |||
| CYP1A (EROD) | Quercetin | ||||
| IC50 | 5.4 (1.5–19.6) | 5.1 (1.7–15.8) | 5.8 (3.2–10.5) | 0.819 | |
| Ki | 1.7 (1.2–2.3) | 2.6 (1.9–3.4) | 2.6 (1.8–3.2) | 0.721 | |
| Naringenin | No inhibition | ||||
| Sesamin | No inhibition | ||||
|
| |||||
| CYP3A (BROD) | Quercetin | ||||
| IC50 | 30.2 (10.4–41.7) | 27.1 (9.3–28.7) | 35.7 (20.4–83.2) | 0.266 | |
| Ki | 67.1 (50.3–83.7) | 64.9 (34.3–76.3) | 75.3 (29.1–93.8) | 0.893 | |
| Naringenin | |||||
| IC50 | 40.3 (9.5–112.3) | 49.1 (11.5–98.4) | 43.1 (20.2–98.5) | 0.925 | |
| Ki | 42.1 (30.3–78.9) | 45.8 (25.6–82.1) | 39.3 (28.5–64.9) | 0.271 | |
| Sesamin | No inhibition | ||||
EROD, 7-ethoxyresorufin O-dealkylase; BROD, 7-benzyloxyresorufin O-dealkylase. Data are presented as geometric means and confidence interval in brackets. P value shows the overall effect of group on IC50 and Ki values.