Table 5.
Pharmacokinetic parameters of BP and BA in rats after intragastric administration.
| Parameters | Unit | Values | |
|---|---|---|---|
| BP | BA | ||
| t 1/2 ∗ | h | 1.97 ± 0.23 | 1.47 ± 0.30 |
| AUC (0–∞)∗ | h ng mL−1 | 102.87 ± 31.74 | 65.81 ± 15.24 |
| MRT (0–∞)∗ | h | 2.27 ± 0.32 | 2.01 ± 0.15 |
| T max ∗ | h | 0.35 ± 0.07 | 0.31 ± 0.03 |
| Cl∗ | h | 1.15 ± 0.34 | 1.74 ± 0.36 |
| V d ∗ | L/h/kg | 3.71 ± 0.35 | 3.79 ± 1.47 |
| C max ∗ | ng/mL | 57.23 ± 17.18 | 49.76 ± 3.51 |
∗ t 1/2: half-life for terminal elimination phase; AUC: area under the time-concentration curve; MRT: mean residence time; Tmax: time to Cmax; Cl: total plasma clearance; Vd: apparent volume of distribution; Cmax: maximum plasma concentration.