Table 2.
Regional differences in gray matter volume between patients with type 2 diabetes and healthy controls in the pooled meta-analysis (voxel-wise p < 0.005 and full-width at half-maximum 20 mm).
| Brain Regions | Maximum | Clusters | |||
|---|---|---|---|---|---|
| MNI coordinates x, y, z | SDM value | p-value | No. voxel | Breakdown (no. of voxels) | |
| Diabetes < control | |||||
| L superior temporal gyrus | -60,-26,10 | -4.865 | 0.000010312 | 548 | L superior temporal gyrus, BA21, 22, 28, 38, 41, 42, 48 (250) |
| L insula, BA 48 (53) | |||||
| L middle temporal gyrus, BA20, 21, 22, 48 (78) | |||||
| L lenticular nucleus, putamen, BA 48 (41) | |||||
| L rolandic operculum, BA 22, 42, 48 (25) | |||||
| L parahippocampal gyrus, BA 28, 35, 36 (39) | |||||
| L amygdala, BA 34 (24) | |||||
| L striatum (15) | |||||
| L inferior frontal gyrus, orbital part, triangular part, opercular part, BA6, 11, 38, 48 (10) | |||||
| L supramarginal gyrus, BA 42, 48 (13) | |||||
| R median cingulate/paracingulate gyri | 2,-6,32 | -4.668 | 0.000038207 | 460 | R median cingulate/ paracingulate gyri, BA4, 23, 24 (89) |
| L median cingulate/ paracingulate gyri, BA23, 24 (89) | |||||
| R precuneus, BA5, 23 (85) | |||||
| L precuneus, BA5, 7, 23 (75) | |||||
| L paracentral lobule, BA4 (35) | |||||
| R paracentral lobule, BA4 (20) | |||||
| L posterior cingulate gyrus, BA14, 26, 30 (29) | |||||
| R posterior cingulate gyrus, BA23, 26, 30 (25) | |||||
| L supplementary motor area, BA4, 6, 23 (21) | |||||
| R supplementary motor area, BA4, 6 (23) | |||||
| R superior temporal gyrus | 58,-10,-4 | -5.224 | ∼0 | 271 | R superior temporal gyrus, BA21, 22, 38, 42, 48 (171) |
| R middle temporal gyrus, BA 21 (11) | |||||
| R insula, BA 48 (12) | |||||
| R post-central gyrus, BA22, 43, 48 (8) R rolandic operculum, BA22, 48 (7) | |||||
| R post-central gyrus, BA22, 43, 48 (12) | |||||
| L superior frontal gyrus, medial | -8,56,8 | -4.350 | 0.000253916 | 83 | L superior frontal gyrus, medial, BA10, 32 (29) |
| R superior frontal gyrus, medial, BA10 (8) | |||||
| L anterior cingulate/paracingulate gyri, BA10, 32 (33) | |||||
| R anterior cingulate/paracingulate gyri, BA10, 32 (13) | |||||
| L middle temporal gyrus | -66,-32,-8 | -4.398 | 0.001219988 | 25 | L middle temporal gyrus, BA21, 22 (25) |
| R gyrus rectus | 10,50,-18 | -4.115 | 0.000847399 | 14 | R gyrus rectus, BA 11 (14) |
| R supramarginal gyrus | 62,-16,26 | -4.184 | 0.000612080 | 11 | R supramarginal gyrus, BA2, 43, 48 (15) |
| R superior frontal gyrus, orbital part | 10,62,-18 | -4.104 | 0.000903130 | 11 | R superior frontal gyrus, orbital, BA 11 (8) |
BA, Brodmann area; L, Left; MNI, Montreal Neurological Institute; R, right; SDM, signed differential mapping.