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. 2012 Jan 9;103(2):228–232. doi: 10.1111/j.1349-7006.2011.02155.x

Figure 4.

Figure 4

 (a) Representative images of mice injected with adenovirus‐mediated siRNA. Control, mice injected with control siRNA; Knockdown, mice injected with plasminogen activator inhibitor‐1 (PAI‐1) knockdown siRNA. Arrows indicate peritoneal metastatic tumors. (b,c) There was a tendency for the number of metastatic tumors (b) and total metastatic tumor volume in mice (n = 10) injected with PAI‐1 RNAi adenovirus to be less than that in the control group, but the differences failed to reach statistical significance (P = 0.09 and 0.07, respectively). (d,e) There were significant reductions in the formation of bloody ascites (d) and tumor incidence (e) in the knockdown group compared with the control group. Data are the mean ± SEM. *P < 0.05.