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. 2017 May 22;24:33. doi: 10.1186/s12929-017-0338-8

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — ALDH2*2 knock-in mice show higher levels of ROS with cisplatin treatment in the cytosolic fraction of lung and brain. ALDH2*2 knock-in mice were treated with cisplatin, euthanized in two days and tissues were collected. Cell homogenates were spun to isolate supernatant, which includes cytosolic fraction from lungs and brains (a and b) and ROS level was measured. Results represent mean ± SEMs (*p < 0.05 vs. PBS HET control (t-test))