Table 3.

Association of cystatin C with depression, based on different definitions of incident depression

Incident depression, defined as	Unadjusted Cox model		Adjusted Cox model1
	1 < cystatin ≤ 1.25	cystatin <1.25	1 < cystatin ≤ 1.25	cystatin <1.25
Depression by medication use and self-report (n = 95)	HR = 1.89 CI = 1.21–2.97 p = 0.006	HR = 2.17 CI = 1.24–3.79 p = 0.007	HR = 1.84 CI = 1.11–3.03 p = 0.02	HR = 2.10 CI = 1.08–4.10 p = 0.03
Depressed mood, CES-D10 ≥10 (n = 664)	HR = 0.91 CI = 0.77–1.08 p = 0.30	HR = 1.11 CI = 0.89–1.39 p = 0.35	HR = 1.01 CI = 0.99–1.04 p = 0.71	HR = 0.97 CI = 0.81–1.15 p = 0.24
Combined incident depressed mood and medication (n = 596)	HR = 0.95 CI = 0.78–1.14 p = 0.57	HR = 1.14 CI = 0.89–1.47 p = 0.29	HR = 0.98 CI = 0.79–1.21 p = 0.83	HR = 1.17 CI = 0.88–1.56 p = 0.29

¹Reference cystatin C <1.0; adjusted for gender, race, living alone status, diabetes and normalized inflammatory biomarkers.