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Mouse Studies and Cytokines Implicated in Precancerous Changes
| Epithelial change | Associated cytokines/cytokine receptors |
|---|---|
| Parietal cell atrophy | IL4, IL6, IL11, IL33, IFN-γ, gp130 receptor |
| Neck cell hyperplasia | IL1, IL6, IFN-γ, gp130 receptor |
| Metaplasia | IL1β, IL6, IL11, IL13, IL33, IFN-γ, gp130 receptor, transforming growth factor-β |
