Table 3. Instrument results at baseline and follow-up timepoints.
| Survey instrument | Follow-up timepoint (months) | No. of patients | Median Score (range) | P-value |
|---|---|---|---|---|
|
| ||||
| FSFI | ||||
|
| ||||
| Arousal | 0 | 30 | 5.0 (0.0-6.0) | --- |
| 1 | 6 | 0.0 (0.0-3.9) | 0.0002 | |
| 6 | 18 | 4.8 (1.2-6.0) | 0.999 | |
| 12 | 13 | 5.1 (0.0-6.0) | 0.900 | |
| 24 | 12 | 3.8 (0.0-6.0) | 0.897 | |
| 36 | 5 | 3.6 (0.0-6.0) | 1.000 | |
| 48 | 4 | 5.9 (0.0-6.0) | 0.975 | |
| 60 | 3 | 4.5 (2.1-5.1) | 0.989 | |
|
| ||||
| Desire | 0 | 30 | 3.6 (1.2-6.0) | --- |
| 1 | 6 | 2.1 (1.2-3.6) | 0.178 | |
| 6 | 18 | 3.9 (1.8-6.0) | 0.902 | |
| 12 | 13 | 4.2 (2.4-5.4) | 0.307 | |
| 24 | 12 | 2.4 (1.2-6.0) | 1.000 | |
| 36 | 5 | 2.4 (1.8-6.0) | 1.000 | |
| 48 | 4 | 4.2 (3.0-4.8) | 0.998 | |
| 60 | 3 | 2.4 (2.4-4.2) | 0.924 | |
|
| ||||
| Lubrication | 0 | 30 | 5.7 (0.0-6.0) | --- |
| 1 | 6 | 0.0 (0.0-4.2) | <0.0001 | |
| 6 | 18 | 5.3 (2.1-6.0) | 0.568 | |
| 12 | 13 | 5.4 (0.0-6.0) | 0.998 | |
| 24 | 12 | 5.1(0.0-6.0) | 1.000 | |
| 36 | 5 | 3.0 (0.0-4.2) | 0.549 | |
| 48 | 4 | 5.0 (0.0-6.0) | 1.000 | |
| 60 | 3 | 4.2 (2.7-5.1) | 1.000 | |
|
| ||||
| Orgasm | 0 | 30 | 5.6 (0.0-6.0) | --- |
| 1 | 6 | 0.0 (0.0-4.4) | 0.006 | |
| 6 | 18 | 4.8 (1.2-6.0) | 0.868 | |
| 12 | 13 | 5.6 (0.0-6.0) | 0.861 | |
| 24 | 12 | 4.2 (0.0-5.6) | 0.992 | |
| 36 | 5 | 2.8 (0.0-6.0) | 0.999 | |
| 48 | 4 | 5.0 (0.0-5.6) | 0.999 | |
| 60 | 3 | 4.0 (3.2-5.6) | 0.876 | |
|
| ||||
| Pain | 0 | 30 | 4.4 (0.0-6.0) | --- |
| 1 | 5 | 0.0 (0.0-0.0) | 0.010 | |
| 6 | 18 | 4.8 (0.0-6.0) | 0.894 | |
| 12 | 13 | 4.8 (0.0-6.0) | 0.999 | |
| 24 | 12 | 4.8 (0.0-6.0) | 0.987 | |
| 36 | 5 | 4.0 (0.0-6.0) | 1.000 | |
| 48 | 4 | 5.0 (0.0-6.0) | 1.000 | |
| 60 | 3 | 4.8 (4.8-5.6) | 0.754 | |
|
| ||||
| Satisfaction | 0 | 30 | 5.2 (0.8-6.0) | --- |
| 1 | 6 | 2.8 (0.0-4.0) | 0.026 | |
| 6 | 18 | 4.4 (1.2-6.0) | 0.965 | |
| 12 | 13 | 5.6 (0.8-6.0) | 0.823 | |
| 24 | 12 | 3.4 (0.8-6.0) | 0.895 | |
| 36 | 5 | 4.4 (0.8-6.0) | 0.875 | |
| 48 | 4 | 5.4 (0.8-6.0) | 0.732 | |
| 60 | 3 | 4.4 (1.6-6.0) | 0.920 | |
|
| ||||
| FSFI Total | 0 | 30 | 27.5 (3.2-36.0) | --- |
| 1 | 5 | 5.8 (3.2-19.7) | 0.004 | |
| 6 | 18 | 27.2 (10.9-35.4) | 0.855 | |
| 12 | 13 | 31.1 (3.2-35.0) | 0.837 | |
| 24 | 12 | 21.6 (2.0-34.4) | 0.969 | |
| 36 | 5 | 20.8 (3.2-32.7) | 1.000 | |
| 48 | 4 | 31.0 (3.8-33.2) | 1.000 | |
| 60 | 3 | 26.1 (17.6-29.0) | 0.985 | |
|
| ||||
| FACT-Cx | ||||
|
| ||||
| Functional well being | 0 | 30 | 21.5 (4.0-28.0) | --- |
| 1 | 25 | 17.0 (5.0-28.0) | 0.019 | |
| 6 | 18 | 27.0 (11.0-28.0) | 0.582 | |
| 12 | 13 | 27.0 (20.0-28.0) | 0.428 | |
| 24 | 12 | 26.5 (16.0-28.0) | 0.295 | |
| 36 | 5 | 24.0 (20.0-27.0) | 0.949 | |
| 48 | 4 | 24.5 (23.0-28.0) | 0.846 | |
| 60 | 3 | 25.0 (24.0-28.0) | 0.762 | |
|
| ||||
| Physical status | 0 | 30 | 26.0 (19.0-28.0) | --- |
| 1 | 25 | 19.0 (1.0-28.0) | <0.0001 | |
| 6 | 18 | 26.9 (17.0-28.0) | 0.995 | |
| 12 | 13 | 26.0 (23.0-28.0) | 1.000 | |
| 24 | 12 | 27.0 (18.0-28.0) | 1.000 | |
| 36 | 5 | 24.5 (20.0-27.0) | 0.750 | |
| 48 | 4 | 21.5 (20.0-28.0) | 0.573 | |
| 60 | 3 | 28.0 (25.0-28.0) | 1.000 | |
|
| ||||
| Emotional well being | 0 | 30 | 16.5 (6.0-23.0) | --- |
| 1 | 25 | 20.0 (13.0-24.0) | 0.004 | |
| 6 | 18 | 20.5 (3.0-24.0) | 0.007 | |
| 12 | 13 | 22.0 (17.0-24.0) | 0.001 | |
| 24 | 12 | 21.0 (13.0-24.0) | 0.002 | |
| 36 | 5 | 18.0 (17.0-23.0) | 0.349 | |
| 48 | 4 | 22.5 (18.0-24.0) | 0.032 | |
| 60 | 3 | 21.0 (20.0-21.0) | 0.194 | |
|
| ||||
| Social/family well being | 0 | 30 | 22.0 (10.0-24.0) | --- |
| 1 | 25 | 21.0 (8.0-24.0) | 0.999 | |
| 6 | 18 | 21.5 (12.0-24.0) | 1.000 | |
| 12 | 13 | 21.0 (15.0-24.0) | 0.967 | |
| 24 | 12 | 21.0 (16.0-24.0) | 0.997 | |
| 36 | 5 | 20.0 (12.0-24.0) | 0.845 | |
| 48 | 4 | 20.0 (12.0-22.0) | 0.572 | |
| 60 | 3 | 23.0 (15.0-24.0) | 1.000 | |
|
| ||||
| FACT-Cx Total | 0 | 30 | 87.0 (46.0-100.0) | --- |
| 1 | 25 | 74.0 (41.0-101.0) | 0.089 | |
| 6 | 18 | 92.0 (51.0-104.0) | 0.875 | |
| 12 | 13 | 93.0 (75.0-104.0) | 0.641 | |
| 24 | 12 | 95.0 (63.0-103.0) | 0.463 | |
| 36 | 5 | 82.0 (78.0-101.0) | 1.000 | |
| 48 | 4 | 86.5 (77.0-102.0) | 1.000 | |
| 60 | 3 | 96.0 (85.0-101.0) | 0.954 | |
|
| ||||
| MDASI | ||||
|
| ||||
| Symptom severity Total | 0 | 30 | 15.0 (0.0-74.0) | --- |
| 1 | 26 | 22.0 (0.0-94.0) | 0.800 | |
| 6 | 18 | 7.5 (0.0-57.0) | 0.869 | |
| 12 | 13 | 6.0 (0.0-26.0) | 0.350 | |
| 24 | 12 | 4.0 (0.0-33.0) | 0.412 | |
| 36 | 5 | 17.0 (3.0-48.0) | 1.000 | |
| 48 | 4 | 15.5 (0.0-22.0) | 0.998 | |
| 60 | 3 | 14.0 (8.0-32.0) | 1.000 | |
|
| ||||
| Symptom distress Total | 0 | 30 | 4.5 (0.0-45.0) | --- |
| 1 | 26 | 9.0 (0.0-60.0) | 0.043 | |
| 6 | 18 | 0.0 (0.0-40.0) | 0.945 | |
| 12 | 13 | 0.0 (0.0-6.0) | 0.523 | |
| 24 | 12 | 0.0 (0.0-22.0) | 0.795 | |
| 36 | 5 | 0.0 (0.0-10.0) | 0.975 | |
| 48 | 4 | 0.0 (0.0-3.0) | 0.924 | |
| 60 | 3 | 6.0 (0.0-6.0) | 1.000 | |
|
| ||||
| SF12 | ||||
|
| ||||
| Bodily pain | 0 | 29 | 5.0 (2.0-5.0) | --- |
| 1 | 26 | 3.0 (1.0-5.0) | <0.0001 | |
| 6 | 18 | 5.0 (3.0-5.0) | 1.000 | |
| 12 | 12 | 5.0 (3.0-5.0) | 1.000 | |
| 24 | 12 | 5.0 (3.0-5.0) | 1.000 | |
| 36 | 4 | 5.0 (4.0-5.0) | 1.000 | |
| 48 | 4 | 5.0 (5.0-5.0) | 0.940 | |
| 60 | 3 | 5.0 (4.0-5.0) | 1.000 | |
|
| ||||
| General health | 0 | 30 | 4.4 (1.0-5.0) | --- |
| 1 | 26 | 4.4 (2.0-5.0) | 0.336 | |
| 6 | 18 | 4.4 (2.0-5.0) | 1.000 | |
| 12 | 11 | 3.4 (2.0-5.0) | 0.779 | |
| 24 | 12 | 4.4 (3.4-5.0) | 1.000 | |
| 36 | 4 | 4.2 (2.0-5.0) | 0.984 | |
| 48 | 4 | 3.9 (3.4-4.4) | 1.000 | |
| 60 | 3 | 4.4 (3.4-5.0) | 1.000 | |
|
| ||||
| Mental health | 0 | 30 | 5.5 (3.0-7.0) | --- |
| 1 | 26 | 5.0 (3.0-7.0) | 0.739 | |
| 6 | 18 | 5.5 (3.0-6.0) | 1.000 | |
| 12 | 13 | 5.0 (3.0-8.0) | 1.000 | |
| 24 | 12 | 5.0 (3.0-6.0) | 1.000 | |
| 36 | 4 | 6.0 (5.0-8.0) | 0.446 | |
| 48 | 4 | 5.5 (4.0-8.0) | 0.779 | |
| 60 | 3 | 6.0 (5.0-6.0) | 0.979 | |
|
| ||||
| Physical functioning | 0 | 30 | 6.0 (2.0-6.0) | --- |
| 1 | 26 | 3.0 (2.0-6.0) | <0.0001 | |
| 6 | 18 | 6.0 (4.0-6.0) | 1.000 | |
| 12 | 13 | 6.0 (3.0-6.0) | 0.981 | |
| 24 | 12 | 6.0 (3.0-6.0) | 1.000 | |
| 36 | 4 | 5.5 (5.0-6.0) | 0.966 | |
| 48 | 4 | 6.0 (5.0-6.0) | 1.000 | |
| 60 | 3 | 6.0 (6.0-6.0) | 1.000 | |
|
| ||||
| Role emotional | 0 | 30 | 8.5 (2.0-10.0) | --- |
| 1 | 26 | 8.0 (2.0-10.0) | 0.030 | |
| 6 | 18 | 9.0 (4.0-10.0) | 0.978 | |
| 12 | 13 | 9.0 (8.0-10.0) | 0.999 | |
| 24 | 12 | 10.0 (9.0-10.0) | 0.734 | |
| 36 | 4 | 9.0 (6.0-10.0) | 0.983 | |
| 48 | 4 | 10.0 (6.0-10.0) | 1.000 | |
| 60 | 3 | 9.0 (8.0-10.0) | 1.000 | |
|
| ||||
| Role physical | 0 | 30 | 10.0 (4.0-10.0) | --- |
| 1 | 26 | 4.0 (2.0-10.0) | <0.0001 | |
| 6 | 18 | 10.0 (6.0-10.0) | 0.985 | |
| 12 | 13 | 9.0 (8.0-10.0) | 1.000 | |
| 24 | 12 | 10.0 (8.0-10.0) | 1.000 | |
| 36 | 4 | 9.0 (8.0-10.0) | 0.991 | |
| 48 | 4 | 10.0 (8.0-10.0) | 1.000 | |
| 60 | 3 | 10.0 (9.0-10.0) | 1.000 | |
|
| ||||
| Social functioning | 0 | 30 | 4.0 (2.0-5.0) | --- |
| 1 | 26 | 4.0 (1.0-5.0) | 0.002 | |
| 6 | 17 | 5.0 (4.0-5.0) | 0.933 | |
| 12 | 12 | 5.0 (4.0-5.0) | 0.963 | |
| 24 | 12 | 5.0 (4.0-5.0) | 0.584 | |
| 36 | 4 | 4.5 (4.0-5.0) | 1.000 | |
| 48 | 4 | 4.5 (2.0-5.0) | 0.936 | |
| 60 | 3 | 4.0 (4.0-5.0) | 1.000 | |
|
| ||||
| Vitality | 0 | 30 | 2.0 (1.0-5.0) | --- |
| 1 | 26 | 2.0 (1.0-5.0) | 0.467 | |
| 6 | 18 | 4.0 (1.0-5.0) | 0.656 | |
| 12 | 13 | 4.0 (1.0-4.0) | 0.940 | |
| 24 | 12 | 4.0 (2.0-5.0) | 0.564 | |
| 36 | 4 | 3.0 (2.0-4.0) | 1.000 | |
| 48 | 4 | 3.0 (2.0-4.0) | 1.000 | |
| 60 | 3 | 4.0 (4.0-4.0) | 0.573 | |
|
| ||||
| SWD | ||||
|
| ||||
| 0 | 28 | 29.0 (6.0-30.0) | --- | |
| 1 | 24 | 29.0 (12.0-30.0) | 0.915 | |
| 6 | 17 | 30.0 (21.6-30.0) | 0.999 | |
| 12 | 10 | 29.5 (22.0-30.0) | 1.000 | |
| 24 | 12 | 26.5 (6.0-30.0) | 0.909 | |
| 36 | 5 | 30.0 (10.8-30.0) | 0.994 | |
| 48 | 4 | 29.0 (24.0-30.0) | 0.971 | |
| 60 | 3 | 24.0 (6.0-30.0) | 0.185 | |
FSFI=Female Sexual Functioning Index, FACT-Cx=Functional Assessment of Cancer Therapy-Cervix, MDASI=MD Anderson Symptom Inventory, SF-12=General Health-Related Quality of Life, SWD=Satisfaction with Decision scale