Skip to main content
. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Curr Opin Organ Transplant. 2016 Dec;21(6):581–587. doi: 10.1097/MOT.0000000000000365

Figure 1.

Figure 1

A. Developmental and regenerative cell lineage relationships of the liver.

B. Hepatic architecture and hepatocyte functional zones of the hepatic lobule. Hepatocyte cords run between portal and central veins. Bile is secreted from hepatocytes into canalicular channels and transported to the bile duct. Sinusoidal capillaries carry higher oxygenated blood supplied by the portal vein and hepatic artery past the hepatocytes toward the central vein. Hepatocytes are arranged into three zones. Zone 1 is composed of periportal hepatocytes and zone 3 is composed of pericentral hepatocytes. Zone 1 hepatocytes specialize in gluconeogenesis and urea formation, while zone 3 hepatocytes specialize in liponeogenesis, glutamine synthesis, and glycolysis.