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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Insect Sci. 2016 Oct 8;19:1–7. doi: 10.1016/j.cois.2016.10.002

Figure 2. The origin of wing spots in D. biarmipes involved changes in cis and trans to the pigmentation-promoting gene yellow.

Figure 2

A novel pattern of yellow gene expression accompanied the evolution of the D. biarmipes wing spot. The evolutionary path to this expression change involved converting a pre-existing wing CRE into the wing+spot CRE by evolving sites for Dll (green) as an activator and En (red) as a repressor. Along this evolutionary path, the Dll activator evolved a strong spot-prefiguring pattern of expression.