Fig. (1).

Model for the establishment of chromosomal instability through the deregulation of cencRNA and the deregulation of CENP-A deposition: several different factors can affect the regulation of cencRNAs, including errors in histone marks that control their expression or stress conditions (such as heat shock). The deregulation of such RNAs causes a defective CENP-A replenishment at the end of mitosis/early G1 as a consequence of inadequate CENP-A chaperone recruitment. Because the same amount of CENP-A is replenished in every cell cycle, it is arguable that a single cencRNA deregulation event may promote the perpetuation of an aberrant CENP-A array and consequently, induce chromosomal instability. However, this hypothesis has not been tested to date.